From the first diagnosis to ongoing education, Pfizer offers a wide variety of tools and resources to help you and your patients manage severe anaphylaxis.
Tools and resources for your practice and to help inform patients
Clinical Criteria Card
Keep a copy of this card in your office for guidelines on diagnosing anaphylaxis and prescribing EpiPen®.
Pharmacist’s Counselling Action Tool
Download this tool for a comprehensive guide to counselling patients on the EpiPen®
Find important information about the EpiPen®
EpiPen® Training Kit and
Order a free kit and use the enclosed trainer to help you practice the steps to using EpiPen® with your patients.
EpiPen® Expiration Reminder Service
Ensure your clinic always has a non-expired EpiPen®
Patient Instruction Sheet
Use this tool to counsel patients on how to use the EpiPen®
Anaphylaxis Education Poster
Display this poster in your clinic to help educate patients on the symptoms of anaphylaxis and how to use EpiPen®.
Tools and resources for your patients
EpiPen® Training Kit
Patients can use the trainer included in this free
EpiPen® Expiration Reminder Service
Patients can register to receive expiration reminders so they always have a non-expired EpiPen®
EpiPen® Reference Cards
These compact cards can help ensure your patients know how to use EpiPen® and where to find practical tools and resources. Available in multiple languages.
EpiPen® Canada Facebook page
Your patients can join our page to get the latest EpiPen® and anaphylaxis news and updates right on their newsfeed.
Frequently asked questions
EpiPen® and EpiPen Jr® (epinephrine)
Click here for complete safety information.
Establish EpiPen® dosage in any specific patient on body weight. The effective dose is usually in the range of 0.005–0.01 mg/kg body weight.
- The EpiPen®
Auto-Injectoris intended for intramuscular administration in adults and children who weigh 30 kg or more.
- The EpiPen®
Auto-Injectordelivers a single intramuscular dose of 0.3 mg epinephrine in a 0.3-mL volume (0.3 mg/0.3 mL).
- The EpiPen Jr®
Auto-Injectoris intended for pediatric intramuscular administration in children who weigh between 15 kg and 30 kg.
- The EpiPen Jr®
Auto-Injectordelivers a single intramuscular dose of 0.15 mg epinephrine in a 0.3-mL volume (0.15 mg/0.3 mL).
Dosing in children (<15 kg):
- Since the dose of epinephrine delivered from EpiPen Jr® is fixed at 0.15 mg, consider other forms of injectable epinephrine if you feel doses lower than 0.15 mg are necessary (eg, children weighing <15 kg).
Dosing in children (>30 kg):
- The EpiPen®
Auto-Injector0.3 mg (adult formulation) is recommended.
Dosage adjustments should be made at the discretion of the healthcare provider.
Remove the EpiPen®
The first dose is used immediately at the first signs and symptoms of a severe allergic reaction.
After administering EpiPen®, patients must go to the nearest emergency room for evaluation and should undergo a period of observation of no less than 4 hours.
Reinject an additional EpiPen®
- Symptoms persist while awaiting transport to the hospital
- Symptoms recur; patients could have a second reaction
- The reaction continues
Do not inject more than 2 injections right after each other.
Anaphylactic reactions typically follow a uniphasic, or single-phase course; however, 20% of severe allergic reactions will have a biphasic, or second-phase reaction.
This second reaction usually occurs after an asymptomatic period of 1 to 8 hours but may occur up to 38 hours (mean 10 hours) after the initial reaction. Second-phase reactions can occur even following administration of corticosteroids.
About 1/3 of the second reactions are more severe, 1/3 are as severe, and 1/3 are less severe.
Due to these risks, patients should seek medical attention immediately and go to the nearest emergency room right after using EpiPen®. For the next 48 hours, patients must stay close to a hospital or where they can call 911.
Multiple doses of epinephrine are also required for long-lasting or protracted anaphylaxis, which is frequently associated with low blood pressure (profound hypotension) and sometimes lasts longer than 24 hours. Protracted anaphylaxis is minimally responsive to aggressive therapy and has a poor prognosis.
Yes. If necessary, EpiPen® can be injected through clothing.
Accidental injection into a hand or foot may result in loss of blood flow to the affected areas and should always be avoided.
If there is an accidental injection into these areas, instruct the patient to go to the nearest emergency room immediately for treatment.
- The viewing window on the barrel of the EpiPen®
Auto-Injector,which is clear prior to delivery, will be obscured or shaded after delivery.
- After EpiPen® is removed from the thigh, the orange needle cover will be extended and locked in place.
- EpiPen® and its extended orange needle cover will not fit into the carrier tube.
Removing the blue safety cap prepares EpiPen® for activation.
If the EpiPen®
- Keep your fingers away from the orange tip.
- Gently place the EpiPen®
Auto-Injectorin its needle-safe carrier tube with the uncovered safety release end at the top.
- Secure the blue safety cap back in place.
Emergency administration of EpiPen® for a suspected severe allergic reaction does not require certification.
Illustrated instructions for using EpiPen® are printed on the barrel of every EpiPen®
Patients and parents of children at risk of a severe allergic reaction are encouraged to actively educate others on how and when to
Pfizer strives for patients to receive a minimum of 12 months before expiry when they purchase EpiPen®
Pfizer does not sell wholesalers any EpiPen®
Encourage patients to verify the expiry date of any new EpiPen®
The EpiPen® Expiration Reminder Service sends alerts one month before, one week before, and on the day a registered EpiPen®
It provides patients with advance notice to reorder and replace their EpiPen®
Visit the EpiPen® Expiration Reminder Service page for more information.
Although there are no adequate and well-controlled studies in pregnant women, EpiPen® should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
EpiPen® contains sodium metabisulphite and may cause allergic-type reactions, including anaphylactic symptoms or mild to severe asthmatic episodes.
Epinephrine is the drug of choice for serious allergic reactions and the presence of a sulphite in EpiPen® should not deter administration of the drug for treatment of serious allergic or other emergency situations, even if the patient is sulphite-sensitive.
- Keep EpiPen® at 25°C (77°F) (room temperature); excursions are permitted to temperatures between 15°C and 30°C
- -Do not refrigerate or freeze
- -Protect EpiPen® from light
- -Do not keep EpiPen® in a vehicle during extremely hot or cold weather
- Keep EpiPen® in its carrier tube to protect it from damage; however, the carrier tube is not waterproof
- Handle with care: The EpiPen®
Auto-Injectoris a medical device that contains glass
An improperly stored EpiPen® is not recommended for use in the event of a severe allergic reaction.
Conditions that can compromise an EpiPen®
- Not storing EpiPen® at the recommended temperature
- Submerging the
- Rough handling
Encourage patients to check the liquid in their EpiPen®
Full instructions for storing EpiPen® are included in the EpiPen® Patient Leaflet.
In Canada, EpiPen® can be purchased with or without a prescription.
However, with a prescription, EpiPen® may be covered for reimbursement by a patient’s drug plan.
Please contact the Pfizer Customer Service Group at 1-800-387-4974.
Pfizer does not have an assistance program for EpiPen®.
Indications and Clinical Use:
- EpiPen® and EpiPen Jr® (epinephrine)
Auto-Injectorsare indicated for the emergency treatment of anaphylactic reactions in patients who are determined to be at increased risk for anaphylaxis, including individuals with a history of anaphylactic reactions.
- Select dose according to patient’s body weight.
- Inject into the outer thigh.
- Following treatment of anaphylaxis, the patient must call 911.
There are no absolute contraindications to the use of epinephrine in a life-threatening allergic situation.
Relevant Warnings and Precautions:
- Avoid use of epinephrine in patients with cardiogenic, traumatic, or hemorrhagic shock; cardiac dilation; cerebral arteriosclerosis; organic brain damage, and narrow-angle glaucoma
- Use with caution in patients with cardiac arrhythmias; coronary artery or organic heart disease; hypertension and hyperthyroidism
- Sulphite sensitivity
- Parkinson’s disease
- Not intended as a substitute for immediate medical care; the patient should seek immediate medical or hospital care
- More than two sequential doses of epinephrine should only be administered under direct medical supervision
- The patient/carer should be informed about the possibility of biphasic anaphylaxis
- Epinephrine should only be injected into the anterolateral aspect of the thigh. Hold child's leg firmly during injection
- Suboptimal effect in patients with a thick subcutaneous fat layer
- Injection site infections
For More Information:
Please consult the prescribing information at www.pfizer.ca/en/our-products/epipen-sterile-epinephrine-injection-usp for more information relating to adverse reactions, drug interactions, and dosing information, which has not been discussed in this advertisement. The prescribing information is also available by calling
EpiPen® and EpiPen Jr® Prescribing Information. Mylan, L.P., September 22, 2020.